The Effect of Collagen on Facial Wrinkles
31 July 2026
The relationship between collagen and aging
One of the first changes we notice in our skin as we age is a decrease in radiance and the appearance of fine lines. Wrinkles around the forehead and eyes are often among the first signs of aging. However, behind this process is not only the passage of time but also collagen, a protein naturally found in our body and essential for skin health.
Although collagen is associated with youth and vitality, it is much more than that. It has a wide range of effects, from skin tension to bone strength, joint flexibility to gut health. Unfortunately, collagen production decreases with age, and this reduction manifests itself as sagging, dryness, and increased wrinkles in the skin.
In this article, we will discuss in detail what collagen is, what it does, how it relates to wrinkles, and what can be done to increase collagen. We will also mention collagen peptides, supplements, supports such as alpha-lipoic acid, and natural methods.
What is collagen?
Collagen is the most abundant protein in our body, making up about 30% of total proteins. Its fibrous structure provides strength to connective tissues. Simply put, collagen is like the "skeleton" of the skin; it provides both support and elasticity to the underlying tissues.
Scientifically, 28 different types of collagen have been identified. Among these, the most important are:
Type I Collagen: It is the main building block of skin, tendons, bones, and teeth.
Type II Collagen: Forms the cartilage structure in joints.
Type III Collagen: Found in muscles, vessel walls, and organs, providing elasticity.
Types I and III collagen are particularly critical for skin health. A decrease in these types leads to thinning skin, loss of elasticity, and the formation of wrinkles.
Collagen is very important for healthy skin.
What does collagen do?
Collagen has critical functions not only for aesthetic reasons but also for overall body health:
Skin health: Maintains moisture balance and elasticity. Delays the formation of fine lines and wrinkles.
Joint health: Supports cartilage tissue, reducing joint pain. Increases mobility, especially in athletes and older age groups.
Bone health: Facilitates the binding of calcium to bones. Has a role in reducing the risk of osteoporosis.
Intestinal health: Strengthens the intestinal barrier, supports digestion, and can act as a protective agent against leaky gut syndrome.
Nail and hair health: Strengthens hair strands, reduces nail breakage.
In short, collagen is a critical molecule not only for "looking young" but also for maintaining overall health.
What do experts say?
HC supplements or collagen peptides can delay and improve the signs of skin aging by reducing facial wrinkles and improving skin hydration and elasticity as long as the supplementation continues.
Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis, Roseane B. de Miranda MD, Patrícia Weimer MD, Rochele C. Rossi PhD
What helps with facial wrinkles?
The biggest reason for wrinkles is the decrease in collagen production. However, there are also environmental and lifestyle factors that accelerate this process:
UV rays from the sun: Damage collagen fibers, causing premature skin aging.
Smoking: Impairs blood circulation, preventing oxygenation of the skin.
Stress: Cortisol hormone negatively affects collagen production.
Insufficient sleep: Reduces the growth hormone necessary for skin regeneration.
The following methods are effective in combating wrinkles:
Using sunscreen: SPF-containing products prevent collagen breakdown.
Eating a diet rich in antioxidants: Vitamin C, vitamin E, and alpha-lipoic acid provide strong support against wrinkles.
Using moisturizer: Protects the skin barrier and reduces the appearance of fine lines.
Dermatological applications: Methods such as retinoid cream, laser treatment, PRP, and mesotherapy can increase collagen production.
Special anti-wrinkle products: Regular use of Retorna Anti-Aging cream, with its active ingredients, helps reduce the appearance of fine lines and support skin elasticity.
Retorna® Anti-Aging Cream, with its intensive care formula developed against the signs of aging, increases skin firmness and elasticity. It helps reduce the appearance of wrinkles and fine lines on the face, around the eyes, neck, and décolleté areas, giving the skin instant radiance and smoothness.
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Powerful anti-wrinkle effect with ARGIRELINE®, HYACARE® 50, and TRYLAGEN™
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Deeply moisturizes, gives skin firmness and plumpness
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100% vegan, not tested on animals, dermatologically tested
What helps with eye wrinkles?
The area around the eyes is where the skin is thinnest, and therefore, collagen loss is noticed more quickly here. Lines known as "crow's feet" often appear at an early age in combination with facial expressions.
Recommendations for the eye area:
Hyaluronic acid and collagen-containing creams increase skin plumpness.
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•Antioxidants such as alpha-lipoic acid and vitamin C reduce free radical damage.
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Getting enough sleep and drinking plenty of water helps reduce the tired and dull appearance around the eyes.
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Wearing sunglasses helps prevent lines and wrinkles triggered by UV rays.
Clinical studies show that individuals who regularly take collagen supplements experience a significant reduction in wrinkles around the eyes after 12 weeks of use. This demonstrates the effects of regular use.
Benefits of collagen
The benefits that can be obtained from regular collagen supplementation are:
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More hydrated and elastic skin
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Reduction in fine lines and wrinkles
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Stronger hair and nail structure
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Alleviation of joint pain
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Increase in bone density
For example, a study published in 2019 showed a significant increase in skin elasticity in women who took 10 grams of collagen supplement daily for 12 weeks. This demonstrates the effects of regular use.
Collagen peptide
The most common form of collagen supplements is collagen peptides. These are large collagen molecules broken down into smaller pieces. This makes them easier to digest and increases their bioavailability.
Collagen peptides act like "signal peptides" in the body. In other words, they send a message to the body to "produce more collagen." Therefore, they not only provide external support but also stimulate natural production.
There are different types according to their sources:
Collagen from fish
It is preferred in skincare products because its small structure makes it easier for the skin to use.
Bovine collagen
Rich in Types I and III, beneficial for both skin and joints.
Chicken collagen
Rich in Type II, especially for joint health.
Collagen supplements
Collagen supplement
Collagen supplements are an effective support method, especially after the age of 25. They can be found in powder, capsule, or liquid form.
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Daily 5–10 grams of hydrolyzed collagen peptide is usually sufficient.
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Taking it with vitamin C increases its absorption.
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For noticeable results, the product should be used regularly for at least 8–12 weeks.
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Care should be taken to ensure that the chosen product does not contain additives, sugar, or artificial sweeteners.
Recent meta-analyses have shown that collagen supplements provide significant benefits in increasing skin elasticity and moisture.
Liquid collagen: benefits and use
Liquid collagen offers easy consumption and, when taken regularly, contributes to a more vibrant, moisturized, and elastic appearance of the skin.
So, how is liquid collagen consumed?
It is generally offered in single-use bottles or measured forms. A daily intake of 5–10 grams is appropriate. Taking it with vitamin C increases its absorption. Noticeable effects can appear when used regularly for 2–3 months.
Alpha Lipoic Acid and collagen
Alpha-lipoic acid (ALA) is a powerful antioxidant and is soluble in both water and fat. This provides protection against free radicals throughout the cells.
One of the mechanisms that support collagen synthesis is the reduction of oxidative stress. ALA comes into play here and prevents the breakdown of existing collagen. It also indirectly supports collagen production due to its ability to reactivate vitamin C and vitamin E.
Natural collagen
Natural collagen sources are mostly found in animal foods; for example, bone broth, fish and chicken skin, and egg whites are among them. In plants, there is no direct collagen, but there are options rich in vitamins and minerals that support its production.
For example:
Pomegranate and grape seed extract: Rich in polyphenols. Green tea: Reduces collagen breakdown with the catechins it contains. Vitamin C-rich vegetables and fruits: Act as cofactors in collagen synthesis.
Frequently Asked Questions
Is collagen only important for the skin?
No. Collagen is critical not only for skin health but also for joint health, bone strength, strengthening of tendons and ligaments, and gut health.
At what age do collagen supplements start to show effects?
With regular use, noticeable results are usually seen within 8–12 weeks. The duration of the effect may vary depending on the individual's metabolism, age, and lifestyle.
Is collagen only for the elderly?
No. Collagen production gradually decreases in the 20s. Early support delays wrinkle formation and protects skin and joint health in the long run.
Collagen is essential for healthy skin, strong joints, and durable bones. Its decreased production is one of the most important causes of aging signs. However, it is possible to slow down this process with a balanced diet, supplements, antioxidant support, and correct lifestyle habits.
The most effective strategy against wrinkles is to take precautions early and regularly support skin health. Regular collagen support is the key not only to a younger appearance but also to a healthier life.
This article was written by Pharmacist Arzum Çetin from the Primum Pharma team.