What is Hyaluronic Acid? Which Type of Hyaluronic Acid Should We Use? What Should We Pay Attention to When Using It?

What is hyaluronic acid?

Hyaluronic acid is a molecule naturally found in our bodies. It is especially abundant in skin, joint, and eye tissues. Due to its structure, hyaluronic acid is an active ingredient with a very high water retention capacity. Thanks to these properties, it helps keep the skin moisturized and protects the skin barrier.

Hyaluronic acid is often referred to as hyaluronic acid or HA in international sources. In its forms used in skincare, low and high molecular weight types are usually found together.

Low molecular weight hyaluronic acid → provides deep hydration by penetrating the deeper layers of the skin

High molecular weight hyaluronic acid → forms a moisture barrier on the upper layer of the skin.

Hyaluronic acid 

What does hyaluronic acid do? What are its benefits?

Intense skin hydration: Hyaluronic acid can hold approximately 1000 times its weight in water. Thanks to this property, the skin appears plumper, more hydrated, and vibrant.

Wrinkles: Moisturizes the skin and provides a plump appearance, which helps reduce the appearance of fine wrinkles (regular use is also very important)

Skin barrier: Helps maintain skin integrity and protects the skin against external factors.

Pore and acne appearance: Especially when used with products containing salicylic acid, niacinamide, and glycolic acid, it can reduce the appearance of pores and balance the skin.

Balance in skincare: When used with products containing retinol or active acids, it can reduce irritation.

Eye area: With its light and water-based structure, it can be easily used in under-eye serums.

How to use hyaluronic acid?

Serum form: Applied to clean and slightly damp skin. For best results, a moisturizer must be applied afterwards.

Cream form: Can be applied directly to the skin as a day or night cream.

In liquid or tonic: Hyaluronic acid can be found as a supportive ingredient in some toners and lotions.

Order of Use:

1. Cleansing

2. Toner (optional)

3. Hyaluronic acid serum

4. Moisturizer

5. If daytime, sunscreen

Which products can be used with hyaluronic acid?

Niacinamide: Strengthens the skin barrier and provides more intense hydration when used together.

Retinol: Can be used with hyaluronic acid to reduce the risk of irritation.

Vitamin C: Forms a powerful combination for the morning routine.

Salicylic Acid & Glycolic Acid: Suitable for skin cleansing and cell renewal, but hyaluronic acid should be used before or after these acids, not at the same time.

Collagen supplements: Creates a synergistic combination to increase skin elasticity. For more information about collagen, click here.

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What should be considered when using hyaluronic acid?

Should be used with a moisturizer or water: If there isn't enough moisture in the environment, hyaluronic acid can draw water from the lower layers of the skin, causing dryness. Therefore, to get the maximum benefit from hyaluronic acid, the product must be applied to skin lightly dampened with water and then sealed with a moisturizing cream.

Avoid excessive concentration: Hyaluronic acid contents above 2% can sometimes cause dryness and tightness in the skin.

Be careful in very dry environments: In dry and enclosed environments, if hyaluronic acid cannot find moisture in its surroundings, it can draw the skin's own moisture to the surface. This can lead to unexpected dryness in the skin.

Pay attention to molecular size: When choosing a product, opting for formulas that combine both low and high molecular weight can provide long-lasting hydration.

Patch test: Especially for sensitive skin, the product should be applied to a small area before use to ensure no allergic reaction develops.

Frequency of use should be adjusted individually: Using it once or twice a day, in the morning and evening, is usually sufficient.

The effect of hyaluronic acid varies depending on its quality. 

What are the side effects and harms of hyaluronic acid?

It is generally considered a skin-friendly ingredient. However, in some cases:

• A slight burning or tightening sensation may occur on the skin.

• It can dry out the skin if used without moisturizing in very dry environments.

• Rarely, it can cause allergic reactions.

Scientific sources emphasize that hyaluronic acid is largely safe, but it will be effective and beneficial when used correctly.

What is HyaCare® 50?

HyaCare® 50 is a special hyaluronic acid with very low molecular weight. It can reach the deeper layers of the skin. Thanks to this property, it provides deep hydration to the skin. Not only does it provide moisture, but it also supports the skin's own hyaluronic acid production, renewing the skin from the inside out.

So, does it really work?

Clinical studies have shown that women who regularly used a cream containing HyaCare® 50 for 2 months experienced:

• A 14% increase in skin elasticity,

• A 36% reduction in the feeling of "looseness" in the skin,

• A 10% reduction in the appearance of deep wrinkles.

A noticeable softening of expression lines, such as crow's feet, has also been reported. These effects result in a smoother, more flexible, and vibrant skin appearance.

Thanks to its light structure, HyaCare® 50 can be easily used even in sensitive areas like around the eyes. Therefore, it is often preferred in anti-aging serums, creams, and eye contour products.

HyaCare® 50 is an active ingredient found in the Retorna product.

Retorna, with its patented active ingredients Argireline®, Hyacare® 50, and Trylagen™, improves the appearance of wrinkles and moisturizes the skin from the first use.

Click on the product name to examine Retorna in more detail.

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What is Hymagic™-4D?

Hymagic™-4D contains 4 types of hyaluronic acid with different molecular sizes. These different types of hyaluronic acid reach different layers of the skin. This provides comprehensive and long-lasting hydration. Products containing Hymagic-4D both moisturize the skin from the surface and penetrate deep into the tissues, repairing it from within and increasing water retention.

Thanks to this four-layered structure:

• Ultra-high molecular weight hyaluronic acid forms a thin protective film on the upper layer of the skin, preventing moisture evaporation and protecting the skin against UV rays.

• Medium molecular weight hyaluronic acid retains water on the skin surface and reduces dryness.

• This easily absorbed hyaluronic acid contributes to the repair of damaged skin surface.

• Very low molecular weight hyaluronic acid quickly reaches the lower layers of the skin, providing deep hydration and repair.

So, does it really work?

Clinical data showed that a lotion containing Hymagic-4D increased skin moisture by 155% in just 1 hour, while also reducing water loss by 32%. These effects demonstrate how effective the product is in keeping the skin hydrated both instantly and long-term, and in increasing its elasticity.

Hymagic™-4D brings water to the skin, ensures its retention, and renews the skin from the inside out. Therefore, it is an innovative active ingredient preferred in many skincare formulas, from anti-aging products to daily moisturizers.

Hymagic™-4D is an active ingredient found in Eva Maree BB Cream.

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Give hyaluronic acid, one of the most talked-about ingredients in skincare in recent years, a chance in your skincare routine.

Frequently Asked Questions

What does hyaluronic acid do?

Hyaluronic acid provides intense hydration to the skin, reduces the appearance of wrinkles, and helps protect the skin barrier. It can also be safely used in sensitive areas around the eyes and on the face.

How should hyaluronic acid be used?

It is applied to clean skin in serum or cream form. For maximum effect, it should be applied when the skin is slightly damp and then sealed with a moisturizer. It can be added to morning and/or evening routines.

What should I pay attention to when using hyaluronic acid?

Skin dryness can occur when used in very dry environments or in excessive concentrations. A patch test is recommended for sensitive skin. Additionally, products that combine both low and high molecular weight forms provide long-lasting hydration.

This article was written by Pharmacist Nil Eker from the Primum Pharma team.